{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":54,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Mohapatra S"],"pubmed_abstract":["INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined. OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer. MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay. RESULTS: Serum vitamin D levels were significantly (p?<?0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype. Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value?<?0.4). CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect."],"journal":["Journal of ovarian research"],"pagination":["37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3668239"],"repository":["biostudies-literature"],"pubmed_title":["Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population."],"pmcid":["PMC3668239"],"pubmed_authors":["Mohapatra S","Ray PC","Saxena A","Gandhi G","Koner BC"],"view_count":["54"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.","description":"INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined. OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer. MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay. RESULTS: Serum vitamin D levels were significantly (p?<?0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype. Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value?<?0.4). CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2021-02-20T05:36:00Z","creation":"2019-06-05T18:41:05Z"},"accession":"S-EPMC3668239","cross_references":{"pubmed":["23705897"],"doi":["10.1186/1757-2215-6-37"]}}