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The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10(-7)), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10(-8)) and BRCA1 mutation carrier (P = 1.1 × 10(-5)) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10(-14))"],"journal":["Nature genetics"],"pubmed_title":["Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer."],"pmcid":["PMC3670748"],"funding_grant_id":["15960","P30 CA008748","13086","C1287/A10118","C12292/A11174","C1287/A10710","R01 CA149429","R01 CA128978","C1287/A9540","P30 CA071789","090532","10118","P30 CA016520","R01 CA122443","03/DHCS/03/G121/51","11022","P30 CA076292","R01 CA112523","16561","16565","110135","11174","P30 CA072720","076113","P50 CA116201","R37 CA070867","BREAST CANCER NOW RESEARCH CENTRE","C1287/A12014","RC4 CA153828","R01 CA092447","P50 CA136393","R01 CA087538","CA116201","U19 CA148112","CA128978","10124","R01 CA083918"],"pubmed_authors":["Flanagan JM","Pankratz VS","Southey MC","Peock S","Nathanson KL","Woods N","Melin B","Sieh W","Labreche F","Fletcher O","Walker L","Shen CY","Bacot F","Mai 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risks of breast and ovarian cancer.","description":"TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10(-7)), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10(-8)) and BRCA1 mutation carrier (P = 1.1 × 10(-5)) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10(-14))","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2026-05-01T04:59:53.769Z","creation":"2026-04-07T16:40:43.114Z"},"accession":"S-EPMC3670748","cross_references":{"pubmed":["23535731"],"doi":["10.1038/ng.2566"]}}