{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(6)"],"submitter":["Chu C"],"pubmed_abstract":["Growing evidence has demonstrated a neuroprotective role of autophagy in Alzheimer's disease (AD). Thus, autophagy has been regarded as a potential therapeutic target, attracting increasing interest in pharmaceutical autophagy modulation by small molecules. We designed a two-cycle screening strategy on the basis of imaging high-throughout screening (HTS) and cellular toxicity assay, and have identified a novel autophagy inducer known as GTM-1. We further showed that GTM-1 exhibits dual activities, such as autophagy induction and antagonism against Aβ-oligomer toxicity. GTM-1 modulates autophagy in an Akt-independent and mTOR-independent manner. In addition, we demonstrated that GTM-1 enhances autophagy clearance and reverses the downregulation of autophagy flux by thapsigargin and asparagine. Furthermore, administration of GTM-1 attenuated Aβ pathology and ameliorated cognitive deficits in AD mice."],"journal":["PloS one"],"pagination":["e65367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3672196"],"repository":["biostudies-literature"],"pubmed_title":["Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits."],"pmcid":["PMC3672196"],"pubmed_authors":["Chu C","Shang L","Zhang X","Wang W","Li L","Fu P","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits.","description":"Growing evidence has demonstrated a neuroprotective role of autophagy in Alzheimer's disease (AD). Thus, autophagy has been regarded as a potential therapeutic target, attracting increasing interest in pharmaceutical autophagy modulation by small molecules. We designed a two-cycle screening strategy on the basis of imaging high-throughout screening (HTS) and cellular toxicity assay, and have identified a novel autophagy inducer known as GTM-1. We further showed that GTM-1 exhibits dual activities, such as autophagy induction and antagonism against Aβ-oligomer toxicity. GTM-1 modulates autophagy in an Akt-independent and mTOR-independent manner. In addition, we demonstrated that GTM-1 enhances autophagy clearance and reverses the downregulation of autophagy flux by thapsigargin and asparagine. Furthermore, administration of GTM-1 attenuated Aβ pathology and ameliorated cognitive deficits in AD mice.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2024-11-05T20:54:26.387Z","creation":"2019-03-26T23:14:38Z"},"accession":"S-EPMC3672196","cross_references":{"pubmed":["23750258"],"doi":["10.1371/journal.pone.0065367"]}}