biostudies-literatureUnknown14(2)Hung LWHoward Hughes Medical InstituteAcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.Journal of structural and functional genomics71-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3679416biostudies-literatureCrystal structure of AcrB complexed with linezolid at 3.5 A resolution.PMC3679416Hung LWKim CYTerwilliger TCGupta GMurakami SKim HBfalseCrystal structure of AcrB complexed with linezolid at 3.5 A resolution.AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.2013-01-01T00:00:00Z2013 Jun2022-02-10T08:37:22.421Z2019-03-27T01:11:27ZS-EPMC36794162367341610.1007/s10969-013-9154-x