{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(6)"],"submitter":["Higareda-Almaraz JC"],"pubmed_abstract":["It has recently begun to be considered that cancer is a systemic disease and that it must be studied at every level of complexity using many of the currently available approaches, including high-throughput technologies and bioinformatics. To achieve such understanding in cervical cancer, we collected information on gene, protein and phosphoprotein expression of the HeLa cell line and performed a comprehensive analysis of the different signaling pathways, transcription networks and metabolic events in which they participate. A total expression analysis by RNA-Seq of the HeLa cell line showed that 19,974 genes were transcribed. Of these, 3,360 were over-expressed, and 2,129 under-expressed when compared to the NHEK cell line. A protein-protein interaction network was derived from the over-ex"],"journal":["PloS one"],"pagination":["e65433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3680226"],"repository":["biostudies-literature"],"pubmed_title":["Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches."],"pmcid":["PMC3680226"],"pubmed_authors":["Higareda-Almaraz JC","Hernandez E","Contreras S","Encarnacion-Guevara S","Encarnacion S","Hernandez-Ortiz M","Valtierra-Gutierrez IA"],"additional_accession":[]},"is_claimable":false,"name":"Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches.","description":"It has recently begun to be considered that cancer is a systemic disease and that it must be studied at every level of complexity using many of the currently available approaches, including high-throughput technologies and bioinformatics. To achieve such understanding in cervical cancer, we collected information on gene, protein and phosphoprotein expression of the HeLa cell line and performed a comprehensive analysis of the different signaling pathways, transcription networks and metabolic events in which they participate. A total expression analysis by RNA-Seq of the HeLa cell line showed that 19,974 genes were transcribed. Of these, 3,360 were over-expressed, and 2,129 under-expressed when compared to the NHEK cell line. A protein-protein interaction network was derived from the over-ex","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-30T09:59:07.157Z","creation":"2026-04-08T06:59:27.424Z"},"accession":"S-EPMC3680226","cross_references":{"pubmed":["23785426"],"doi":["10.1371/journal.pone.0065433"]}}