biostudies-literatureAllen ASNIMH NIH HHSNHLBI NIH HHS973-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3685412biostudies-literatureUnknown153B(4)Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsSNPs in CAST are associated with Parkinson disease: a confirmation study.PMC3685412R01 MH084680-02K25 HL077663R01 MH084680Allen ASSatten GAfalseSNPs in CAST are associated with Parkinson disease: a confirmation study.Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.2010-01-01T00:00:00Z2010 Jun2024-11-15T22:31:44.14Z2019-03-27T01:11:47ZS-EPMC36854122012788410.1002/ajmg.b.31061