{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(6)"],"submitter":["Su CW"],"pubmed_abstract":["<h4>Background</h4>Whether or not hepatitis B virus (HBV) genotypes, mutations, and viral loads determine outcomes for patients with HBV-induced hepatocellular carcinoma (HCC) remains controversial.<h4>Aims</h4>To study the influence of HBV viral factors on prognoses for patients with HBV-induced HCC after resection surgery and investigate if antiviral therapy could counteract the adverse effects of viral factors.<h4>Methods</h4>A total of 333 HBV-related HCC patients who underwent tumor resection were enrolled retrospectively. Serum HBV DNA levels, mutations, anti-viral therapy, and other clinical variables were analyzed for their association with post-operative recurrence.<h4>Results</h4>After a median follow-up of 45.9 months, 208 patients had HCC recurrence after resection. The 5-year "],"journal":["PloS one"],"pagination":["e66457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3689837"],"repository":["biostudies-literature"],"pubmed_title":["The Influence of Hepatitis B Viral Load and Pre-S Deletion Mutations on Post-Operative Recurrence of Hepatocellular Carcinoma and the Tertiary Preventive Effects by Anti-Viral Therapy."],"pmcid":["PMC3689837"],"pubmed_authors":["Chiou YW","Huo TI","Wu JC","Su CW","Tsai YH","Teng RD","Lei HJ","Chau GY","Hung HH"],"additional_accession":[]},"is_claimable":false,"name":"The Influence of Hepatitis B Viral Load and Pre-S Deletion Mutations on Post-Operative Recurrence of Hepatocellular Carcinoma and the Tertiary Preventive Effects by Anti-Viral Therapy.","description":"<h4>Background</h4>Whether or not hepatitis B virus (HBV) genotypes, mutations, and viral loads determine outcomes for patients with HBV-induced hepatocellular carcinoma (HCC) remains controversial.<h4>Aims</h4>To study the influence of HBV viral factors on prognoses for patients with HBV-induced HCC after resection surgery and investigate if antiviral therapy could counteract the adverse effects of viral factors.<h4>Methods</h4>A total of 333 HBV-related HCC patients who underwent tumor resection were enrolled retrospectively. Serum HBV DNA levels, mutations, anti-viral therapy, and other clinical variables were analyzed for their association with post-operative recurrence.<h4>Results</h4>After a median follow-up of 45.9 months, 208 patients had HCC recurrence after resection. The 5-year ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-04T14:21:35.708Z","creation":"2026-04-07T20:34:50.949Z"},"accession":"S-EPMC3689837","cross_references":{"pubmed":["23805222"],"doi":["10.1371/journal.pone.0066457"]}}