biostudies-literatureUnknown8(6)Su CW<h4>Background</h4>Whether or not hepatitis B virus (HBV) genotypes, mutations, and viral loads determine outcomes for patients with HBV-induced hepatocellular carcinoma (HCC) remains controversial.<h4>Aims</h4>To study the influence of HBV viral factors on prognoses for patients with HBV-induced HCC after resection surgery and investigate if antiviral therapy could counteract the adverse effects of viral factors.<h4>Methods</h4>A total of 333 HBV-related HCC patients who underwent tumor resection were enrolled retrospectively. Serum HBV DNA levels, mutations, anti-viral therapy, and other clinical variables were analyzed for their association with post-operative recurrence.<h4>Results</h4>After a median follow-up of 45.9 months, 208 patients had HCC recurrence after resection. The 5-year PloS onee66457https://www.ebi.ac.uk/biostudies/studies/S-EPMC3689837biostudies-literatureThe Influence of Hepatitis B Viral Load and Pre-S Deletion Mutations on Post-Operative Recurrence of Hepatocellular Carcinoma and the Tertiary Preventive Effects by Anti-Viral Therapy.PMC3689837Chiou YWHuo TIWu JCSu CWTsai YHTeng RDLei HJChau GYHung HHfalseThe Influence of Hepatitis B Viral Load and Pre-S Deletion Mutations on Post-Operative Recurrence of Hepatocellular Carcinoma and the Tertiary Preventive Effects by Anti-Viral Therapy.<h4>Background</h4>Whether or not hepatitis B virus (HBV) genotypes, mutations, and viral loads determine outcomes for patients with HBV-induced hepatocellular carcinoma (HCC) remains controversial.<h4>Aims</h4>To study the influence of HBV viral factors on prognoses for patients with HBV-induced HCC after resection surgery and investigate if antiviral therapy could counteract the adverse effects of viral factors.<h4>Methods</h4>A total of 333 HBV-related HCC patients who underwent tumor resection were enrolled retrospectively. Serum HBV DNA levels, mutations, anti-viral therapy, and other clinical variables were analyzed for their association with post-operative recurrence.<h4>Results</h4>After a median follow-up of 45.9 months, 208 patients had HCC recurrence after resection. The 5-year 2013-01-01T00:00:00Z20132026-05-04T14:21:35.708Z2026-04-07T20:34:50.949ZS-EPMC36898372380522210.1371/journal.pone.0066457