biostudies-literatureWu QJthe National Institutes of HealthUnited States National Institutes of HealthFIC NIH HHSNHLBI NIH HHSState Key Project Specialized for Infectious Diseases of ChinaNCI NIH HHSFogarty International Center, NIH, through an R24 Training Grant1918-1924https://www.ebi.ac.uk/biostudies/studies/S-EPMC3690909biostudies-literatureUnknown24(7)<h4>Background</h4>Epidemiological studies evaluating the association between cruciferous vegetables (CVs) intake and female lung cancer risk have produced inconsistent results.<h4>Patients and methods</h4>This study followed 74 914 Chinese women aged 40-70 years who participated in the Shanghai Women's Health Study. CV intake was assessed through a validated food-frequency questionnaire (FFQ) at baseline and reassessed during follow-up. Hazard ratios (HRs) and 95% confidence interval (CIs) were estimated by using Cox proportional hazards models. Furthermore, we carried out a meta-analysis of all observational studies until December 2011.<h4>Results</h4>After excluding the first 2 years of follow-up, 417 women developed lung cancer over a mean of 11.1 years of follow-up. An inverse association of borderline statistical significance was observed between CV consumption and female lung cancer risk, with HR for the highest compared with the lowest quartiles of 0.73 (95% CI 0.54-1.00, P trend = 0.1607). The association was strengthened in analyses restricting to never smokers, with the corresponding HR of 0.59 (95% CI 0.40-0.87, P trend = 0.0510). The finding of an inverse association between CV intake and lung cancer risk in women was supported by our meta-analysis of 10 included studies.<h4>Conclusions</h4>Our study suggests that CV consumption may reduce the risk of lung cancer in women, particularly among never smokers.Annals of oncology : official journal of the European Society for Medical OncologyCruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.PMC3690909No. 2008ZX10002-015 and 2012ZX10002008-002R01 HL095931R24TW007988-55R25 CA047888R37CA070867R37 CA070867, R01 CA82729 and R01 HL095931R01 CA827295R25CA047888Ji BTVogtmann EYang GWu QJShu XOGao YTLi HLXie LXiang YBZheng WfalseCruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.<h4>Background</h4>Epidemiological studies evaluating the association between cruciferous vegetables (CVs) intake and female lung cancer risk have produced inconsistent results.<h4>Patients and methods</h4>This study followed 74 914 Chinese women aged 40-70 years who participated in the Shanghai Women's Health Study. CV intake was assessed through a validated food-frequency questionnaire (FFQ) at baseline and reassessed during follow-up. Hazard ratios (HRs) and 95% confidence interval (CIs) were estimated by using Cox proportional hazards models. Furthermore, we carried out a meta-analysis of all observational studies until December 2011.<h4>Results</h4>After excluding the first 2 years of follow-up, 417 women developed lung cancer over a mean of 11.1 years of follow-up. An inverse association of borderline statistical significance was observed between CV consumption and female lung cancer risk, with HR for the highest compared with the lowest quartiles of 0.73 (95% CI 0.54-1.00, P trend = 0.1607). The association was strengthened in analyses restricting to never smokers, with the corresponding HR of 0.59 (95% CI 0.40-0.87, P trend = 0.0510). The finding of an inverse association between CV intake and lung cancer risk in women was supported by our meta-analysis of 10 included studies.<h4>Conclusions</h4>Our study suggests that CV consumption may reduce the risk of lung cancer in women, particularly among never smokers.2013-01-01T00:00:00Z2013 Jul2025-04-19T17:09:35.695Z2019-03-27T01:12:03ZS-EPMC36909092355305910.1093/annonc/mdt119