biostudies-literatureUnknown12Bosco N<h4>Background</h4>Inflammatory bowel diseases (IBD) are chronic intestinal inflammatory diseases affecting about 1% of western populations. New eating behaviors might contribute to the global emergence of IBD. Although the immunoregulatory effects of omega-3 fatty acids have been well characterized in vitro, their role in IBD is controversial.<h4>Methods</h4>The aim of this study was to assess the impact of increased fish oil intake on colonic gene expression, eicosanoid metabolism and development of colitis in a mouse model of IBD. Rag-2 deficient mice were fed fish oil (FO) enriched in omega-3 fatty acids i.e. EPA and DHA or control diet for 4 weeks before colitis induction by adoptive transfer of naïve T cells and maintained in the same diet for 4 additional weeks. Onset of colitis wasLipids in health and disease81https://www.ebi.ac.uk/biostudies/studies/S-EPMC3691874biostudies-literatureEffects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis.PMC3691874Lichti PRezzi SMetairon SBastic Schmid VBosco NMansourian RPace-Asciak CBenyacoub JOliveira MMartin FPBrahmbhatt VRaymond FHaller DfalseEffects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis.<h4>Background</h4>Inflammatory bowel diseases (IBD) are chronic intestinal inflammatory diseases affecting about 1% of western populations. New eating behaviors might contribute to the global emergence of IBD. Although the immunoregulatory effects of omega-3 fatty acids have been well characterized in vitro, their role in IBD is controversial.<h4>Methods</h4>The aim of this study was to assess the impact of increased fish oil intake on colonic gene expression, eicosanoid metabolism and development of colitis in a mouse model of IBD. Rag-2 deficient mice were fed fish oil (FO) enriched in omega-3 fatty acids i.e. EPA and DHA or control diet for 4 weeks before colitis induction by adoptive transfer of naïve T cells and maintained in the same diet for 4 additional weeks. Onset of colitis was2013-01-01T00:00:00Z2013 May2025-04-19T11:23:47.108Z2019-03-27T01:12:06ZS-EPMC36918742372508610.1186/1476-511X-12-81