{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brennan JC"],"funding":["NCRR NIH HHS","NIEHS NIH HHS","PHS HHS"],"pagination":["133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3695784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Background
The plant genus Fallopia is well-known in Chinese traditional medicine and includes many species that contain bioactive compounds, namely phytoestrogens. Consumption of phytoestrogens may be linked to decreased incidence of breast and prostate cancers therefore discovery of novel phytoestrogens and novel sources of phytoestrogens is of interest. Although phytoestrogen content has been analyzed in the rhizomes of various Fallopia sp., seeds of a Fallopia sp. have never been examined for phytoestrogen presence.Methods
Analytical chemistry techniques were used with guidance from an in vitro estrogen receptor bioassay (a stably transfected human ovarian carcinoma cell line) to isolate and identify estrogenic components from seeds of Fallopia convolvulus. A transientl"],"journal":["BMC complementary and alternative medicine"],"pubmed_title":["2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines."],"pmcid":["PMC3695784"],"funding_grant_id":["ESO04699","RR11973","T32 ES007059","T32 ES007058-33","P42 ES004699"],"pubmed_authors":["Dallas JL","Magiatis P","Millam JR","Soshilov AA","Holstege DM","Gutierrez EG","Brennan JC","Denison MS"],"additional_accession":[]},"is_claimable":false,"name":"2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines.","description":"Background
The plant genus Fallopia is well-known in Chinese traditional medicine and includes many species that contain bioactive compounds, namely phytoestrogens. Consumption of phytoestrogens may be linked to decreased incidence of breast and prostate cancers therefore discovery of novel phytoestrogens and novel sources of phytoestrogens is of interest. Although phytoestrogen content has been analyzed in the rhizomes of various Fallopia sp., seeds of a Fallopia sp. have never been examined for phytoestrogen presence.Methods
Analytical chemistry techniques were used with guidance from an in vitro estrogen receptor bioassay (a stably transfected human ovarian carcinoma cell line) to isolate and identify estrogenic components from seeds of Fallopia convolvulus. A transientl","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jun","modification":"2026-05-30T13:46:18.456Z","creation":"2019-03-27T01:12:15Z"},"accession":"S-EPMC3695784","cross_references":{"pubmed":["23768005"],"doi":["10.1186/1472-6882-13-133"]}}