biostudies-literatureUnknown8(6)Ferrandez-Ayela AThe selective trafficking of proteins and RNAs through the nuclear envelope regulates nuclear-cytoplasmic segregation of macromolecules and is mediated by nucleopore complexes (NPCs), which consist of about 400 nucleoporins (Nups) of about 30 types. Extensive studies of nucleoporin function in yeast and vertebrates showed that Nups function in nucleocytoplasmic trafficking and other processes. However, limited studies of plant Nups have identified only a few mutations, which cause pleiotropic phenotypes including reduced growth and early flowering. Here, we describe loss-of-function alleles of Arabidopsis TRANSCURVATA1 (TCU1); these mutations cause increased hypocotyl and petiole length, reticulate and asymmetrically epinastic leaf laminae of reduced size, and early flowering. TCU1 is tranPloS onee67661https://www.ebi.ac.uk/biostudies/studies/S-EPMC3695937biostudies-literatureArabidopsis TRANSCURVATA1 encodes NUP58, a component of the nucleopore central channel.PMC3695937Micol-Ponce RAlonso-Peral MMFerrandez-Ayela AMicol JLSanchez-Garcia ABPonce MRPerez-Perez JMfalseArabidopsis TRANSCURVATA1 encodes NUP58, a component of the nucleopore central channel.The selective trafficking of proteins and RNAs through the nuclear envelope regulates nuclear-cytoplasmic segregation of macromolecules and is mediated by nucleopore complexes (NPCs), which consist of about 400 nucleoporins (Nups) of about 30 types. Extensive studies of nucleoporin function in yeast and vertebrates showed that Nups function in nucleocytoplasmic trafficking and other processes. However, limited studies of plant Nups have identified only a few mutations, which cause pleiotropic phenotypes including reduced growth and early flowering. Here, we describe loss-of-function alleles of Arabidopsis TRANSCURVATA1 (TCU1); these mutations cause increased hypocotyl and petiole length, reticulate and asymmetrically epinastic leaf laminae of reduced size, and early flowering. TCU1 is tran2013-01-01T00:00:00Z20132026-05-30T10:08:59.208Z2019-03-26T23:14:59ZS-EPMC36959372384076110.1371/journal.pone.0067661