{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sherwood EJ"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["E2500-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3704008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(27)"],"pubmed_abstract":["Planosporicin is a ribosomally synthesized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora alba. It contains one methyl-lanthionine and four lanthionine bridges and inhibits cell wall biosynthesis in other Gram-positive bacteria probably by binding to lipid II, the immediate precursor for cell wall biosynthesis. Planosporicin production, which is encoded by a cluster of 15 genes, is confined to stationary phase in liquid culture and to the onset of morphological differentiation when P. alba is grown on agar. This growth phase-dependent gene expression is controlled transcriptionally by three pathway-specific regulatory proteins: an extracytoplasmic function σ factor (PspX), its cognate anti-σ factor (PspW), and a transcriptional activator (PspR"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba."],"pmcid":["PMC3704008"],"funding_grant_id":["BB/J004561/1","BBS/E/J/00000607"],"pubmed_authors":["Bibb MJ","Sherwood EJ"],"additional_accession":[]},"is_claimable":false,"name":"The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba.","description":"Planosporicin is a ribosomally synthesized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora alba. It contains one methyl-lanthionine and four lanthionine bridges and inhibits cell wall biosynthesis in other Gram-positive bacteria probably by binding to lipid II, the immediate precursor for cell wall biosynthesis. Planosporicin production, which is encoded by a cluster of 15 genes, is confined to stationary phase in liquid culture and to the onset of morphological differentiation when P. alba is grown on agar. This growth phase-dependent gene expression is controlled transcriptionally by three pathway-specific regulatory proteins: an extracytoplasmic function σ factor (PspX), its cognate anti-σ factor (PspW), and a transcriptional activator (PspR","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jul","modification":"2025-04-04T23:24:53.034Z","creation":"2019-03-27T01:12:38Z"},"accession":"S-EPMC3704008","cross_references":{"pubmed":["23776227"],"doi":["10.1073/pnas.1305392110"]}}