biostudies-literatureSherwood EJBiotechnology and Biological Sciences Research CouncilE2500-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3704008biostudies-literatureUnknown110(27)Planosporicin is a ribosomally synthesized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora alba. It contains one methyl-lanthionine and four lanthionine bridges and inhibits cell wall biosynthesis in other Gram-positive bacteria probably by binding to lipid II, the immediate precursor for cell wall biosynthesis. Planosporicin production, which is encoded by a cluster of 15 genes, is confined to stationary phase in liquid culture and to the onset of morphological differentiation when P. alba is grown on agar. This growth phase-dependent gene expression is controlled transcriptionally by three pathway-specific regulatory proteins: an extracytoplasmic function σ factor (PspX), its cognate anti-σ factor (PspW), and a transcriptional activator (PspRProceedings of the National Academy of Sciences of the United States of AmericaThe antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba.PMC3704008BB/J004561/1BBS/E/J/00000607Bibb MJSherwood EJfalseThe antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba.Planosporicin is a ribosomally synthesized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora alba. It contains one methyl-lanthionine and four lanthionine bridges and inhibits cell wall biosynthesis in other Gram-positive bacteria probably by binding to lipid II, the immediate precursor for cell wall biosynthesis. Planosporicin production, which is encoded by a cluster of 15 genes, is confined to stationary phase in liquid culture and to the onset of morphological differentiation when P. alba is grown on agar. This growth phase-dependent gene expression is controlled transcriptionally by three pathway-specific regulatory proteins: an extracytoplasmic function σ factor (PspX), its cognate anti-σ factor (PspW), and a transcriptional activator (PspR2013-01-01T00:00:00Z2013 Jul2025-04-04T23:24:53.034Z2019-03-27T01:12:38ZS-EPMC37040082377622710.1073/pnas.1305392110