{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiaii S"],"funding":["National Institute for Health Research (NIHR)","NCI NIH HHS"],"pagination":["2654-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3709054"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(21)"],"pubmed_abstract":["<h4>Purpose</h4>Previous studies have demonstrated the prognostic importance of the immune microenvironment in follicular lymphoma (FL). To investigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL microenvironment, we studied highly purified CD4 and CD8 TILs from lymph node biopsies at diagnosis in treatment-naive patients with FL compared with reactive tonsils and the peripheral blood of healthy donors.<h4>Patients and methods</h4>Gene expression profiling of highly purified CD4 and CD8 TILs was performed on the Affymetrix platform. Diagnostic tissue microarrays from an independent patient set (n = 172) were used to verify protein expression and analyze any impact of TIL-expressed genes on outcome. Time-lapse imaging was used to assess T-ce"],"journal":["Journal of clinical oncology : official journal of the American Society of Clinical Oncology"],"pubmed_title":["Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation."],"pmcid":["PMC3709054"],"funding_grant_id":["P01 CA081534","CL-2007-19-002"],"pubmed_authors":["Neuberg DS","Lee A","Sangaralingam A","Calaminici M","Gribben JG","Clear AJ","Ramsay AG","Davies D","Kiaii S"],"additional_accession":[]},"is_claimable":false,"name":"Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation.","description":"<h4>Purpose</h4>Previous studies have demonstrated the prognostic importance of the immune microenvironment in follicular lymphoma (FL). To investigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL microenvironment, we studied highly purified CD4 and CD8 TILs from lymph node biopsies at diagnosis in treatment-naive patients with FL compared with reactive tonsils and the peripheral blood of healthy donors.<h4>Patients and methods</h4>Gene expression profiling of highly purified CD4 and CD8 TILs was performed on the Affymetrix platform. Diagnostic tissue microarrays from an independent patient set (n = 172) were used to verify protein expression and analyze any impact of TIL-expressed genes on outcome. Time-lapse imaging was used to assess T-ce","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jul","modification":"2026-06-04T17:16:19.675Z","creation":"2019-03-26T22:59:43Z"},"accession":"S-EPMC3709054","cross_references":{"pubmed":["23775959"],"doi":["10.1200/JCO.2012.44.2137","10.1200/jco.2012.44.2137"]}}