{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Czyzewski BK"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NIGMS NIH HHS"],"pagination":["494-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3711795"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["483(7390)"],"pubmed_abstract":["The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory and dissimilatory sulphate reduction. These pathways can reduce various oxidized sulphur compounds including sulphate, sulphite and thiosulphate. The dissimilatory sulphate reduction pathway uses this molecule as the terminal electron acceptor for anaerobic respiration, in which process it produces excess amounts of H(2)S (ref. 4). The reduction of sulphite is a key intermediate step in all sulphate reduction pathways. In Clostridium and Salmonella, an inducible sulphite reduc"],"journal":["Nature"],"pubmed_title":["Identification and characterization of a bacterial hydrosulphide ion channel."],"pmcid":["PMC3711795"],"funding_grant_id":["U54 GM075026","R01-MH083840","R01-DK073973","R01 MH083840","R01-GM093825","R01-DK053973-08A1S1","U54-GM075026","R01 DK053973","F31 AI086072","R01 GM093825","R01 DK073973","F31-AI086072"],"pubmed_authors":["Wang DN","Czyzewski BK"],"additional_accession":[]},"is_claimable":false,"name":"Identification and characterization of a bacterial hydrosulphide ion channel.","description":"The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory and dissimilatory sulphate reduction. These pathways can reduce various oxidized sulphur compounds including sulphate, sulphite and thiosulphate. The dissimilatory sulphate reduction pathway uses this molecule as the terminal electron acceptor for anaerobic respiration, in which process it produces excess amounts of H(2)S (ref. 4). The reduction of sulphite is a key intermediate step in all sulphate reduction pathways. In Clostridium and Salmonella, an inducible sulphite reduc","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-05-30T11:51:48.38Z","creation":"2026-04-08T07:10:25.117Z"},"accession":"S-EPMC3711795","cross_references":{"pubmed":["22407320"],"doi":["10.1038/nature10881"]}}