biostudies-literatureYamamoto JKNIAID NIH HHS14-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC3721975biostudies-literatureUnknown8(1)Feline immunodeficiency virus (FIV) discovered in 1986 is a lentivirus that causes AIDS in domestic cats. FIV is classified into five subtypes (A-E), and all subtypes and circulating intersubtype recombinants have been identified throughout the world. A commercial FIV vaccine, consisting of inactivated subtype-A and -D viruses (Fel-O-Vax FIV, Fort Dodge Animal Health), was released in the United States in 2002. The United States Department of Agriculture approved the commercial release of Fel-O-Vax FIV based on two efficacy trials using 105 laboratory cats and a major safety trial performed on 689 pet cats. The prototype and commercial FIV vaccines had broad prophylactic efficacy against global FIV subtypes and circulating intersubtype recombinants. The mechanisms of cross-subtype efficacyCurrent HIV researchFeline immunodeficiency virus model for designing HIV/AIDS vaccines.PMC3721975R01 AI030904R01 AI065276R01-AI065276R01-AI030904Sanou MPYamamoto JKAbbott JRColeman JKfalseFeline immunodeficiency virus model for designing HIV/AIDS vaccines.Feline immunodeficiency virus (FIV) discovered in 1986 is a lentivirus that causes AIDS in domestic cats. FIV is classified into five subtypes (A-E), and all subtypes and circulating intersubtype recombinants have been identified throughout the world. A commercial FIV vaccine, consisting of inactivated subtype-A and -D viruses (Fel-O-Vax FIV, Fort Dodge Animal Health), was released in the United States in 2002. The United States Department of Agriculture approved the commercial release of Fel-O-Vax FIV based on two efficacy trials using 105 laboratory cats and a major safety trial performed on 689 pet cats. The prototype and commercial FIV vaccines had broad prophylactic efficacy against global FIV subtypes and circulating intersubtype recombinants. The mechanisms of cross-subtype efficacy2010-01-01T00:00:00Z2010 Jan2025-04-26T10:57:30.675Z2019-06-05T18:58:15ZS-EPMC37219752021077810.2174/157016210790416361