biostudies-literatureMcLaren PJIntramural NIH HHSHoward Hughes Medical InstituteNIDA NIH HHSNIAID NIH HHSNHLBI NIH HHSPHS HHSe1003515https://www.ebi.ac.uk/biostudies/studies/S-EPMC3723635biostudies-literatureUnknown9(7)Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA varianPLoS pathogensAssociation study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.PMC3723635T32 AI007140HHSN26120080001EP01 AI057005R37 AI047734U01 DA036297UM1 AI069496R01 DA012568R01 HL087676Walker BDvan Manen DGoldstein DBMcLaren PJHerbeck JTZagury JFRipke SCossarizza AHaas DTheodorou IPoli GWolinsky SSchuitemaker HFellay JMullins JIO'Brien SJde Bakker PIQi YDe Luca ADelaneau OMartinez-Picado JVannberg FKathiresan SGoedert JJRucart PWinkler CAShea PRCoulonges CCarrington MMeyer LObel NMiro JMLambotte OWeintrob AKirk GDPereyra FMallal SPlummer FATelenti ALuo MSandhu MSBuchbinder SDalmau Jvan den Berg LVeldink JDeeks SGfalseAssociation study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA varian2013-01-01T00:00:00Z20132026-05-05T18:30:33.555Z2026-04-07T21:47:06.733ZS-EPMC37236352393548910.1371/journal.ppat.1003515