biostudies-literatureKook SNCI NIH HHS3420-35https://www.ebi.ac.uk/biostudies/studies/S-EPMC3726149biostudies-literatureUnknown123(8)Hematopoietic stem progenitor cells (HSPCs) are present in very small numbers in the circulating blood in steady-state conditions. In response to stress or injury, HSPCs are primed to migrate out of their niche to peripheral blood. Mobilized HSPCs are now commonly used as stem cell sources due to faster engraftment and reduced risk of posttransplant infection. In this study, we demonstrated that a nucleotide sugar, UDP-glucose, which is released into extracellular fluids in response to stress, mediates HSPC mobilization. UDP-glucose-mobilized cells possessed the capacity to achieve long-term repopulation in lethally irradiated animals and the ability to differentiate into multi-lineage blood cells. Compared with G-CSF-mobilized cells, UDP-glucose-mobilized cells preferentially supported loThe Journal of clinical investigationThe nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.PMC3726149P30 CA047904P30CA047904Cho JKook SLee BCLee SBfalseThe nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.Hematopoietic stem progenitor cells (HSPCs) are present in very small numbers in the circulating blood in steady-state conditions. In response to stress or injury, HSPCs are primed to migrate out of their niche to peripheral blood. Mobilized HSPCs are now commonly used as stem cell sources due to faster engraftment and reduced risk of posttransplant infection. In this study, we demonstrated that a nucleotide sugar, UDP-glucose, which is released into extracellular fluids in response to stress, mediates HSPC mobilization. UDP-glucose-mobilized cells possessed the capacity to achieve long-term repopulation in lethally irradiated animals and the ability to differentiate into multi-lineage blood cells. Compared with G-CSF-mobilized cells, UDP-glucose-mobilized cells preferentially supported lo2013-01-01T00:00:00Z2013 Aug2025-04-19T02:34:37.918Z2019-03-27T00:14:24ZS-EPMC37261492386371310.1172/JCI6406010.1172/jci64060