{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cook RS"],"funding":["NCRR NIH HHS","NCI NIH HHS"],"pagination":["3231-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3726162"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123(8)"],"pubmed_abstract":["MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumors grew slowly and were poorly metastatic in MerTK-/- mice. Transplantation of MerTK-/- bone marrow, but not wild-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic breast cancer) decreased tumor growth and altered cytokine production by tumor CD11b+ cells. Although MerTK expression was not required for tumor infiltration by leukocytes, MerTK-/- leukocytes exhibited lower tumor cell-induced expression of wound healing cytokines, e.g., IL-10 and growth arrest-specif"],"journal":["The Journal of clinical investigation"],"pubmed_title":["MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis."],"pmcid":["PMC3726162"],"funding_grant_id":["P30 CA046934","P50 CA058223","P30 CA016086","R01 CA143126","P50 CA098131","T32 CA009592","UL1 RR025780","P50 CA98131"],"pubmed_authors":["Wofford AM","Cook RS","Stanford J","Hunter DM","Prieto AL","Sandahl M","Graham DK","DeRyckere D","Earp HS","Strunk KE","Jacobsen KM","Redente E"],"additional_accession":[]},"is_claimable":false,"name":"MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.","description":"MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumors grew slowly and were poorly metastatic in MerTK-/- mice. Transplantation of MerTK-/- bone marrow, but not wild-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic breast cancer) decreased tumor growth and altered cytokine production by tumor CD11b+ cells. Although MerTK expression was not required for tumor infiltration by leukocytes, MerTK-/- leukocytes exhibited lower tumor cell-induced expression of wound healing cytokines, e.g., IL-10 and growth arrest-specif","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Aug","modification":"2025-04-19T17:07:10.662Z","creation":"2019-03-27T01:13:44Z"},"accession":"S-EPMC3726162","cross_references":{"pubmed":["23867499"],"doi":["10.1172/jci67655","10.1172/JCI67655"]}}