{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["210(8)"],"submitter":["Wang XX"],"pubmed_abstract":["Mumps commonly affects children 5-9 yr of age, and can lead to permanent adult sterility in certain cases. However, the etiology of this long-term effect remains unclear. Mumps infection results in progressive degeneration of the seminiferous epithelium and, occasionally, Sertoli cell-only syndrome. Thus, the remaining Sertoli cells may be critical to spermatogenesis recovery after orchitis healing. Here, we report that the protein farnesylation/geranylgeranylation balance is critical for patients' fertility. The expression of geranylgeranyl diphosphate synthase 1 (GGPPS) was decreased due to elevated promoter methylation in the testes of infertile patients with mumps infection history. When we deleted GGPPS in mouse Sertoli cells, these cells remained intact, whereas the adjacent spermato"],"journal":["The Journal of experimental medicine"],"pagination":["1559-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3727317"],"repository":["biostudies-literature"],"pubmed_title":["Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection."],"pmcid":["PMC3727317"],"pubmed_authors":["Sun HX","Ying P","Chen WB","Diao F","Shen N","Jiang S","Tang H","Wang Q","Xu ZP","Li CJ","Sha JH","Wang XX","Miao XL","Tao WW","Zhao NW","Xu N","Huang XX","Shi QH","Feng J","Ye D","Li JM","Jiang C","Yao B","Lai SS","Gao X"],"additional_accession":[]},"is_claimable":false,"name":"Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection.","description":"Mumps commonly affects children 5-9 yr of age, and can lead to permanent adult sterility in certain cases. However, the etiology of this long-term effect remains unclear. Mumps infection results in progressive degeneration of the seminiferous epithelium and, occasionally, Sertoli cell-only syndrome. Thus, the remaining Sertoli cells may be critical to spermatogenesis recovery after orchitis healing. Here, we report that the protein farnesylation/geranylgeranylation balance is critical for patients' fertility. The expression of geranylgeranyl diphosphate synthase 1 (GGPPS) was decreased due to elevated promoter methylation in the testes of infertile patients with mumps infection history. When we deleted GGPPS in mouse Sertoli cells, these cells remained intact, whereas the adjacent spermato","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jul","modification":"2026-05-30T11:57:37.899Z","creation":"2019-03-27T01:13:47Z"},"accession":"S-EPMC3727317","cross_references":{"pubmed":["23825187"],"doi":["10.1084/jem.20121806"]}}