{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Reichelt J"],"pubmed_abstract":["The expression of distinct keratin pairs during epidermal differentiation is assumed to fulfill specific and essential cytoskeletal functions. This is supported by a great variety of genodermatoses exhibiting tissue fragility because of keratin mutations. Here, we show that the loss of K10, the most prominent epidermal protein, allowed the formation of a normal epidermis in neonatal mice without signs of fragility or wound-healing response. However, there were profound changes in the composition of suprabasal keratin filaments. K5/14 persisted suprabasally at elevated protein levels, whereas their mRNAs remained restricted to the basal keratinocytes. This indicated a novel mechanism regulating keratin turnover. Moreover, the amount of K1 was reduced. In the absence of its natural partner w"],"journal":["Molecular biology of the cell"],"pagination":["1557-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC37324"],"repository":["biostudies-literature"],"pubmed_title":["Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice."],"pmcid":["PMC37324"],"pubmed_authors":["Grund C","Magin TM","Reichelt J","Bussow H"],"additional_accession":[]},"is_claimable":false,"name":"Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.","description":"The expression of distinct keratin pairs during epidermal differentiation is assumed to fulfill specific and essential cytoskeletal functions. This is supported by a great variety of genodermatoses exhibiting tissue fragility because of keratin mutations. Here, we show that the loss of K10, the most prominent epidermal protein, allowed the formation of a normal epidermis in neonatal mice without signs of fragility or wound-healing response. However, there were profound changes in the composition of suprabasal keratin filaments. K5/14 persisted suprabasally at elevated protein levels, whereas their mRNAs remained restricted to the basal keratinocytes. This indicated a novel mechanism regulating keratin turnover. Moreover, the amount of K1 was reduced. In the absence of its natural partner w","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Jun","modification":"2025-04-27T02:49:05.108Z","creation":"2019-03-26T23:43:00Z"},"accession":"S-EPMC37324","cross_references":{"pubmed":["11408568"],"doi":["10.1091/mbc.12.6.1557"]}}