{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Minvielle MJ"],"funding":["NIGMS NIH HHS"],"pagination":["916-919"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3733276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(6)"],"pubmed_abstract":["Herein is described a method of accessing indole/triazole and benzothiophene/triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into a biofilm inducer. Isosteric replacement of the indole core by a benzothiophene significantly impaired anti-biofilm activity. A competition assay exposing <i>Escherichia coli</i> to the most potent biofilm inducer and an inhibitor of <i>E. coli</i> biofilm formation was performed. The inducer exhibited the ability to mute the effect of the anti-biofilm compound for this targeted bacterial population."],"journal":["MedChemComm"],"pubmed_title":["Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms."],"pmcid":["PMC3733276"],"funding_grant_id":["R01 GM055769"],"pubmed_authors":["Minvielle MJ","Bunders CA","Melander C"],"additional_accession":[]},"is_claimable":false,"name":"Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms.","description":"Herein is described a method of accessing indole/triazole and benzothiophene/triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into a biofilm inducer. Isosteric replacement of the indole core by a benzothiophene significantly impaired anti-biofilm activity. A competition assay exposing <i>Escherichia coli</i> to the most potent biofilm inducer and an inhibitor of <i>E. coli</i> biofilm formation was performed. The inducer exhibited the ability to mute the effect of the anti-biofilm compound for this targeted bacterial population.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jun","modification":"2025-04-07T13:01:30.368Z","creation":"2019-03-26T23:51:07Z"},"accession":"S-EPMC3733276","cross_references":{"pubmed":["23930199"],"doi":["10.1039/C3MD00064H","10.1039/c3md00064h"]}}