{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(8)"],"submitter":["Wang HI"],"pubmed_abstract":["Multipartite viruses contain more than one distinctive genome component, and the origin of multipartite viruses has been suggested to evolve from a non-segmented wild-type virus. To explore whether recombination also plays a role in the evolution of the genomes of multipartite viruses, we developed a systematic approach that employs motif-finding tools to detect conserved motifs from divergent genomic regions and applies statistical approaches to select high-confidence motifs. The information that this approach provides helps us understand the evolution of viruses. In this study, we compared our motif-based strategy with current alignment-based recombination-detecting methods and applied our methods to the analysis of multipartite single-stranded plant DNA viruses, including bipartite bego"],"journal":["PloS one"],"pagination":["e71565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3735576"],"repository":["biostudies-literature"],"pubmed_title":["Application of motif-based tools on evolutionary analysis of multipartite single-stranded DNA viruses."],"pmcid":["PMC3735576"],"pubmed_authors":["Tang C","Chang CH","Yeh HH","Fu HC","Lin PH","Wang HI"],"additional_accession":[]},"is_claimable":false,"name":"Application of motif-based tools on evolutionary analysis of multipartite single-stranded DNA viruses.","description":"Multipartite viruses contain more than one distinctive genome component, and the origin of multipartite viruses has been suggested to evolve from a non-segmented wild-type virus. To explore whether recombination also plays a role in the evolution of the genomes of multipartite viruses, we developed a systematic approach that employs motif-finding tools to detect conserved motifs from divergent genomic regions and applies statistical approaches to select high-confidence motifs. The information that this approach provides helps us understand the evolution of viruses. In this study, we compared our motif-based strategy with current alignment-based recombination-detecting methods and applied our methods to the analysis of multipartite single-stranded plant DNA viruses, including bipartite bego","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-30T09:11:46.544Z","creation":"2025-07-28T03:04:15.791Z"},"accession":"S-EPMC3735576","cross_references":{"pubmed":["23936517"],"doi":["10.1371/journal.pone.0071565"]}}