{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holcomb JB"],"funding":["NCATS NIH HHS","NCRR NIH HHS"],"pagination":["127-36"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3740072"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(2)"],"pubmed_abstract":["<h4>Objective</h4>To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.<h4>Design</h4>Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.<h4>Setting</h4>Ten US level I trauma centers.<h4>Patients</h4>Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).<h4>Main outcome measure</h4>In-hospital mortality.<h4>Results</h4>Plasma:RBC and p"],"journal":["JAMA surgery"],"pubmed_title":["The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks."],"pmcid":["PMC3740072"],"funding_grant_id":["UL1 RR024148","UL1 TR000005"],"pubmed_authors":["Holcomb JB","Muskat P","Underwood SJ","Zhang J","Johannigman JA","Robinson BR","Rahbar MH","Cotton BA","Alarcon LH","Carroll E","Coates EC","Scerbo M","Sambucini RL","Elopre M","White CE","Zolin SJ","Knudson M","Wang W","Podbielski J","Gildea M","Caga-Anan Z","Shnol HL","Branson R","McCarthy J","Reynolds RJ","Nelson M","Brasel KJ","Bulger EM","Hatch QM","Jonas R","Matijevic N","Curren J","Stull SD","Wade CE","PROMMTT Study Group","Benjamin-Garner R","Minei JP","Dahl C","Klotz P","Gomaa D","Early BJ","DeRosa M","Warner KJ","Myers JG","Call MS","Cohen MJ","Sears SB","Franzen KL","Phelan HA","Bai Y","Walsh P","Peitzman AB","Duran SJ","Kampmeyer M","Fox EE","Stewart RM","del Junco DJ","Schreiber MA"],"additional_accession":[]},"is_claimable":false,"name":"The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.","description":"<h4>Objective</h4>To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.<h4>Design</h4>Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.<h4>Setting</h4>Ten US level I trauma centers.<h4>Patients</h4>Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).<h4>Main outcome measure</h4>In-hospital mortality.<h4>Results</h4>Plasma:RBC and p","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2026-04-16T23:21:17.548Z","creation":"2026-04-07T14:22:57.84Z"},"accession":"S-EPMC3740072","cross_references":{"pubmed":["23560283"],"doi":["10.1001/2013.jamasurg.387"]}}