biostudies-literatureHolcomb JBNCATS NIH HHSNCRR NIH HHS127-36https://www.ebi.ac.uk/biostudies/studies/S-EPMC3740072biostudies-literatureUnknown148(2)<h4>Objective</h4>To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.<h4>Design</h4>Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.<h4>Setting</h4>Ten US level I trauma centers.<h4>Patients</h4>Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).<h4>Main outcome measure</h4>In-hospital mortality.<h4>Results</h4>Plasma:RBC and pJAMA surgeryThe prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.PMC3740072UL1 RR024148UL1 TR000005Holcomb JBMuskat PUnderwood SJZhang JJohannigman JARobinson BRRahbar MHCotton BAAlarcon LHCarroll ECoates ECScerbo MSambucini RLElopre MWhite CEZolin SJKnudson MWang WPodbielski JGildea MCaga-Anan ZShnol HLBranson RMcCarthy JReynolds RJNelson MBrasel KJBulger EMHatch QMJonas RMatijevic NCurren JStull SDWade CEPROMMTT Study GroupBenjamin-Garner RMinei JPDahl CKlotz PGomaa DEarly BJDeRosa MWarner KJMyers JGCall MSCohen MJSears SBFranzen KLPhelan HABai YWalsh PPeitzman ABDuran SJKampmeyer MFox EEStewart RMdel Junco DJSchreiber MAfalseThe prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.<h4>Objective</h4>To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.<h4>Design</h4>Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.<h4>Setting</h4>Ten US level I trauma centers.<h4>Patients</h4>Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).<h4>Main outcome measure</h4>In-hospital mortality.<h4>Results</h4>Plasma:RBC and p2013-01-01T00:00:00Z2013 Feb2026-04-16T23:21:17.548Z2026-04-07T14:22:57.84ZS-EPMC37400722356028310.1001/2013.jamasurg.387