{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Kurpet MK"],"pubmed_abstract":["A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivatives of 4-nitropyrazole, 2-nitroimidazole, 4(5)-nitroimidazole and 3-nitro-1,2,4-triazole."],"journal":["Beilstein journal of organic chemistry"],"pagination":["1517-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3740504"],"repository":["biostudies-literature"],"pubmed_title":["Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles."],"pmcid":["PMC3740504"],"pubmed_authors":["Kuznik N","Dabrowska A","Jarosz MM","Kajewska-Kania K","Suwinski JW","Kurpet MK"],"additional_accession":[]},"is_claimable":false,"name":"Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles.","description":"A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivatives of 4-nitropyrazole, 2-nitroimidazole, 4(5)-nitroimidazole and 3-nitro-1,2,4-triazole.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2021-02-21T09:23:35Z","creation":"2019-03-27T01:14:26Z"},"accession":"S-EPMC3740504","cross_references":{"pubmed":["23946851"],"doi":["10.3762/bjoc.9.173"]}}