biostudies-literatureRohlfs RVNIGMS NIH HHSe70495https://www.ebi.ac.uk/biostudies/studies/S-EPMC3743829biostudies-literatureUnknown8(8)We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches. We carried out a simulation study of randomly generated profiles of related and unrelated individuals with 13-locus CODIS genotypes and YFiler® Y-chromosome haplotypes, on which the Myers protocol for relative identification was carried out. For Y-chromosome sharing first degree relatives, the Myers protocol has a high probability (80~99%) of identifying their relationship. For unrelated individuals, there is a low probability that an unrelated person in the database will be identified as a first-degree relative. For more distant Y-haplotype sharing relatives (half-siblings, first cousins, half-first cousins or second cousins) therPloS oneThe influence of relatives on the efficiency and error rate of familial searching.PMC3743829R01 GM040282R01-GM40282Slatkin MRohlfs RVSong YSMurphy EfalseThe influence of relatives on the efficiency and error rate of familial searching.We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches. We carried out a simulation study of randomly generated profiles of related and unrelated individuals with 13-locus CODIS genotypes and YFiler® Y-chromosome haplotypes, on which the Myers protocol for relative identification was carried out. For Y-chromosome sharing first degree relatives, the Myers protocol has a high probability (80~99%) of identifying their relationship. For unrelated individuals, there is a low probability that an unrelated person in the database will be identified as a first-degree relative. For more distant Y-haplotype sharing relatives (half-siblings, first cousins, half-first cousins or second cousins) ther2013-01-01T00:00:00Z20132026-05-07T00:48:21.013Z2026-04-07T22:21:46.855ZS-EPMC37438292396707610.1371/journal.pone.0070495