{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(8)"],"submitter":["Billeskov R"],"pubmed_abstract":["Here we report for the first time on the immunogenicity and protective efficacy of a vaccine strategy involving the adjuvanted fusion protein \"H28\" (consisting of Ag85B-TB10.4-Rv2660c) and Modified Vaccinia Virus Ankara expressing H28. We show that a heterologous prime-boost regimen involving priming with H28 in a Th1 adjuvant followed by boosting with H28 expressed by MVA (H28/MVA28) induced the highest percentage of IFN-γ expressing T cells, the highest production of IFN-γ per single cell and the highest induction of CD8 T cells compared to either of the vaccines given alone. In contrast, in mice vaccinated with adjuvanted recombinant H28 alone (H28/H28) we observed the highest production of IL-2 per single cell and the highest frequency of antigen specific TNF-α/IL-2 expressing CD4 T ce"],"journal":["PloS one"],"pagination":["e72185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3747044"],"repository":["biostudies-literature"],"pubmed_title":["Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model."],"pmcid":["PMC3747044"],"pubmed_authors":["Dietrich J","Billeskov R","Christensen JP","Aagaard C","Andersen P"],"additional_accession":[]},"is_claimable":false,"name":"Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model.","description":"Here we report for the first time on the immunogenicity and protective efficacy of a vaccine strategy involving the adjuvanted fusion protein \"H28\" (consisting of Ag85B-TB10.4-Rv2660c) and Modified Vaccinia Virus Ankara expressing H28. We show that a heterologous prime-boost regimen involving priming with H28 in a Th1 adjuvant followed by boosting with H28 expressed by MVA (H28/MVA28) induced the highest percentage of IFN-γ expressing T cells, the highest production of IFN-γ per single cell and the highest induction of CD8 T cells compared to either of the vaccines given alone. In contrast, in mice vaccinated with adjuvanted recombinant H28 alone (H28/H28) we observed the highest production of IL-2 per single cell and the highest frequency of antigen specific TNF-α/IL-2 expressing CD4 T ce","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-06-01T04:04:43.159Z","creation":"2025-06-01T04:04:43.159Z"},"accession":"S-EPMC3747044","cross_references":{"pubmed":["23977248"],"doi":["10.1371/journal.pone.0072185"]}}