{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["208(6)"],"submitter":["Heller T"],"pubmed_abstract":["<h4>Background</h4>T-cell responses have been described in seronegative patients who test negative for hepatitis C virus (HCV) RNA despite frequent HCV exposure. However, the cross-sectional design of those studies did not clarify whether T cells were indeed induced by low-level HCV exposure without seroconversion or whether they resulted from regular acute infection with subsequent antibody loss.<h4>Methods</h4>Over a 10-year period, our longitudinal study recruited 72 healthcare workers with documented HCV exposure. We studied viremia and antibody and T-cell responses longitudinally for 6 months.<h4>Results</h4>All healthcare workers remained negative for HCV RNA and antibodies. However, 48% developed proliferative T-cell response and 42% developed responses in interferon-gamma enzyme-li"],"journal":["The Journal of infectious diseases"],"pagination":["1020-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3749009"],"repository":["biostudies-literature"],"pubmed_title":["Occupational exposure to hepatitis C virus: early T-cell responses in the absence of seroconversion in a longitudinal cohort study."],"pmcid":["PMC3749009"],"pubmed_authors":["Sherker AH","Rahman F","Gordon AM","Bean KS","Mizukoshi E","Heller T","Herrine SK","Stevens M","Kessler E","Sobao Y","Schmitt J","Rehermann B","Werner JM","Sheets A"],"additional_accession":[]},"is_claimable":false,"name":"Occupational exposure to hepatitis C virus: early T-cell responses in the absence of seroconversion in a longitudinal cohort study.","description":"<h4>Background</h4>T-cell responses have been described in seronegative patients who test negative for hepatitis C virus (HCV) RNA despite frequent HCV exposure. However, the cross-sectional design of those studies did not clarify whether T cells were indeed induced by low-level HCV exposure without seroconversion or whether they resulted from regular acute infection with subsequent antibody loss.<h4>Methods</h4>Over a 10-year period, our longitudinal study recruited 72 healthcare workers with documented HCV exposure. We studied viremia and antibody and T-cell responses longitudinally for 6 months.<h4>Results</h4>All healthcare workers remained negative for HCV RNA and antibodies. However, 48% developed proliferative T-cell response and 42% developed responses in interferon-gamma enzyme-li","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Sep","modification":"2025-04-22T16:30:54.79Z","creation":"2019-03-27T01:14:48Z"},"accession":"S-EPMC3749009","cross_references":{"pubmed":["23801608"],"doi":["10.1093/infdis/jit270"]}}