{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Waldo JP"],"funding":["NIGMS NIH HHS"],"pagination":["658-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3750120"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated."],"journal":["Journal of combinatorial chemistry"],"pubmed_title":["Solution phase synthesis of a diverse library of highly substituted isoxazoles."],"pmcid":["PMC3750120"],"funding_grant_id":["R01 GM070620","R01 GM079593","P41 GM079593","P50 GM069663"],"pubmed_authors":["Larock RC","Neuenswander B","Mehta S","Waldo JP","Lushington GH"],"additional_accession":[]},"is_claimable":false,"name":"Solution phase synthesis of a diverse library of highly substituted isoxazoles.","description":"The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Sep-Oct","modification":"2025-04-20T03:03:35.732Z","creation":"2019-03-27T01:14:52Z"},"accession":"S-EPMC3750120","cross_references":{"pubmed":["18671435"],"doi":["10.1021/cc800055x"]}}