biostudies-literatureWaldo JPNIGMS NIH HHS658-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC3750120biostudies-literatureUnknown10(5)The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.Journal of combinatorial chemistrySolution phase synthesis of a diverse library of highly substituted isoxazoles.PMC3750120R01 GM070620R01 GM079593P41 GM079593P50 GM069663Larock RCNeuenswander BMehta SWaldo JPLushington GHfalseSolution phase synthesis of a diverse library of highly substituted isoxazoles.The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.2008-01-01T00:00:00Z2008 Sep-Oct2025-04-20T03:03:35.732Z2019-03-27T01:14:52ZS-EPMC37501201867143510.1021/cc800055x