{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wisby L"],"funding":["Medical Research Council"],"pagination":["242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3751763"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["<h4>Background</h4>Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.<h4>Results</h4>In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.<h4>Conclusions</h4>The two quantitative trait loci we have ide"],"journal":["BMC genomics"],"pubmed_title":["Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice."],"pmcid":["PMC3751763"],"funding_grant_id":["G0501416","MC_U142684174"],"pubmed_authors":["Kadioglu A","Fernandes VE","Andrew PW","Wisby L","Denny P","Neill DR"],"additional_accession":[]},"is_claimable":false,"name":"Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.","description":"<h4>Background</h4>Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.<h4>Results</h4>In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.<h4>Conclusions</h4>The two quantitative trait loci we have ide","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2026-05-06T21:38:23.656Z","creation":"2026-04-07T22:22:10.947Z"},"accession":"S-EPMC3751763","cross_references":{"pubmed":["23577770"],"doi":["10.1186/1471-2164-14-242"]}}