biostudies-literatureWisby LMedical Research Council242https://www.ebi.ac.uk/biostudies/studies/S-EPMC3751763biostudies-literatureUnknown14<h4>Background</h4>Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.<h4>Results</h4>In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.<h4>Conclusions</h4>The two quantitative trait loci we have ideBMC genomicsSpir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.PMC3751763G0501416MC_U142684174Kadioglu AFernandes VEAndrew PWWisby LDenny PNeill DRfalseSpir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.<h4>Background</h4>Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.<h4>Results</h4>In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.<h4>Conclusions</h4>The two quantitative trait loci we have ide2013-01-01T00:00:00Z2013 Apr2026-05-06T21:38:23.656Z2026-04-07T22:22:10.947ZS-EPMC37517632357777010.1186/1471-2164-14-242