{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Katsumura KR"],"funding":["NIDDK NIH HHS","NIGMS NIH HHS"],"pagination":["a015412"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3753722"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(9)"],"pubmed_abstract":["The physiological switch in expression of the embryonic, fetal, and adult β-like globin genes has garnered enormous attention from investigators interested in transcriptional mechanisms and the molecular basis of hemoglobinopathies. These efforts have led to the discovery of cell type-specific transcription factors, unprecedented mechanisms of transcriptional coregulator function, genome biology principles, unique contributions of nuclear organization to transcription and cell function, and promising therapeutic targets. Given the vast literature accrued on this topic, this article will focus on the master regulator of erythroid cell development and function GATA-1, its associated proteins, and its frontline role in controlling hemoglobin synthesis. GATA-1 is a crucial regulator of genes encoding hemoglobin subunits and heme biosynthetic enzymes. GATA-1-dependent mechanisms constitute an essential regulatory core that nucleates additional mechanisms to achieve the physiological control of hemoglobin synthesis."],"journal":["Cold Spring Harbor perspectives in medicine"],"pubmed_title":["Transcriptional mechanisms underlying hemoglobin synthesis."],"pmcid":["PMC3753722"],"funding_grant_id":["DK50107","T32 GM081061","R01 DK050107","R37 DK050107"],"pubmed_authors":["Katsumura KR","DeVilbiss AW","Johnson KD","Pope NJ","Bresnick EH"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional mechanisms underlying hemoglobin synthesis.","description":"The physiological switch in expression of the embryonic, fetal, and adult β-like globin genes has garnered enormous attention from investigators interested in transcriptional mechanisms and the molecular basis of hemoglobinopathies. These efforts have led to the discovery of cell type-specific transcription factors, unprecedented mechanisms of transcriptional coregulator function, genome biology principles, unique contributions of nuclear organization to transcription and cell function, and promising therapeutic targets. Given the vast literature accrued on this topic, this article will focus on the master regulator of erythroid cell development and function GATA-1, its associated proteins, and its frontline role in controlling hemoglobin synthesis. GATA-1 is a crucial regulator of genes encoding hemoglobin subunits and heme biosynthetic enzymes. GATA-1-dependent mechanisms constitute an essential regulatory core that nucleates additional mechanisms to achieve the physiological control of hemoglobin synthesis.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Sep","modification":"2024-12-03T19:50:14.639Z","creation":"2019-03-27T01:15:05Z"},"accession":"S-EPMC3753722","cross_references":{"pubmed":["23838521"],"doi":["10.1101/cshperspect.a015412"]}}