{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(17)"],"submitter":["Tsuchiya Y"],"pubmed_abstract":["Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of human diseases, including neurodegenerative disorders. Thus, stimulating proteasome activity is a promising strategy to ameliorate these age-related diseases. Here we show that the protein kinase casein kinase 2 (CK2) regulates the transcriptional activity of Nrf1 to control the expression of the proteasome genes and thus the clearance of ubiquitinated proteins. We identify CK2 as an Nrf1-binding protein and find that the knockdown of CK2 enhances the Nrf1-dependent expression of the proteasome subunit genes. Real-time monitoring of proteasome activity reveals that CK2 knockdown alleviates the accumulation of ubiquitinated proteins upon proteasome inhibition. Furthermore, we identify Ser 497 of N"],"journal":["Molecular and cellular biology"],"pagination":["3461-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3753846"],"repository":["biostudies-literature"],"pubmed_title":["The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression."],"pmcid":["PMC3753846"],"pubmed_authors":["Ito T","Okamuro S","Ito Y","Nishida E","Fukagai K","Tsuchiya Y","Morita T","Ohtake N","Natsume T","Kobayashi A","Karim MR","Iemura S","Taniguchi H"],"additional_accession":[]},"is_claimable":false,"name":"The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.","description":"Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of human diseases, including neurodegenerative disorders. Thus, stimulating proteasome activity is a promising strategy to ameliorate these age-related diseases. Here we show that the protein kinase casein kinase 2 (CK2) regulates the transcriptional activity of Nrf1 to control the expression of the proteasome genes and thus the clearance of ubiquitinated proteins. We identify CK2 as an Nrf1-binding protein and find that the knockdown of CK2 enhances the Nrf1-dependent expression of the proteasome subunit genes. Real-time monitoring of proteasome activity reveals that CK2 knockdown alleviates the accumulation of ubiquitinated proteins upon proteasome inhibition. Furthermore, we identify Ser 497 of N","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Sep","modification":"2025-04-04T22:06:39.345Z","creation":"2019-03-27T01:15:06Z"},"accession":"S-EPMC3753846","cross_references":{"pubmed":["23816881"],"doi":["10.1128/MCB.01271-12","10.1128/mcb.01271-12"]}}