biostudies-literatureUnknown14(3)Bhattacharyya SGallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl4)-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl4-induced group (P < 0.05 and P < 0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.AAPS PharmSciTech1025-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC3755146biostudies-literatureThe gallic acid-phospholipid complex improved the antioxidant potential of gallic acid by enhancing its bioavailability.PMC3755146Mukherjee PKBhattacharyya SSaha BPAhammed SMfalseThe gallic acid-phospholipid complex improved the antioxidant potential of gallic acid by enhancing its bioavailability.Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl4)-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl4-induced group (P < 0.05 and P < 0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.2013-01-01T00:00:00Z2013 Sep2025-04-04T23:24:24.5Z2019-03-27T01:15:10ZS-EPMC37551462380085710.1208/s12249-013-9991-8