{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(9)"],"submitter":["Lai TY"],"pubmed_abstract":["Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which recognizes the lipopolysaccharides (LPS) on Gram-positive and Gram-negative bacteria, triggers downstream signaling mediators and eventually activates IκB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-κB, a core transcription factor of the innate immune response, the induction of some LPS-induced genes in macrophages required another transcription factor whose activity depends on p38. However, these additional transcription factors remain to be "],"journal":["PloS one"],"pagination":["e73153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3759409"],"repository":["biostudies-literature"],"pubmed_title":["Transcription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages."],"pmcid":["PMC3759409"],"pubmed_authors":["Lai LC","Chuang EY","Lai TY","Chuang LL","Hsu LC","Tsai MH","Wu SD"],"additional_accession":[]},"is_claimable":false,"name":"Transcription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages.","description":"Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which recognizes the lipopolysaccharides (LPS) on Gram-positive and Gram-negative bacteria, triggers downstream signaling mediators and eventually activates IκB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-κB, a core transcription factor of the innate immune response, the induction of some LPS-induced genes in macrophages required another transcription factor whose activity depends on p38. However, these additional transcription factors remain to be ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-04-07T21:13:25.491Z","creation":"2026-04-07T18:00:31.552Z"},"accession":"S-EPMC3759409","cross_references":{"pubmed":["24023826"],"doi":["10.1371/journal.pone.0073153"]}}