biostudies-literatureUnknown8(9)Lai TYMacrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which recognizes the lipopolysaccharides (LPS) on Gram-positive and Gram-negative bacteria, triggers downstream signaling mediators and eventually activates IκB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-κB, a core transcription factor of the innate immune response, the induction of some LPS-induced genes in macrophages required another transcription factor whose activity depends on p38. However, these additional transcription factors remain to be PloS onee73153https://www.ebi.ac.uk/biostudies/studies/S-EPMC3759409biostudies-literatureTranscription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages.PMC3759409Lai LCChuang EYLai TYChuang LLHsu LCTsai MHWu SDfalseTranscription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages.Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which recognizes the lipopolysaccharides (LPS) on Gram-positive and Gram-negative bacteria, triggers downstream signaling mediators and eventually activates IκB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-κB, a core transcription factor of the innate immune response, the induction of some LPS-induced genes in macrophages required another transcription factor whose activity depends on p38. However, these additional transcription factors remain to be 2013-01-01T00:00:00Z20132026-04-07T21:13:25.491Z2026-04-07T18:00:31.552ZS-EPMC37594092402382610.1371/journal.pone.0073153