{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ammitzboll CG"],"funding":["NHLBI NIH HHS"],"pagination":["e73317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3759447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(9)"],"pubmed_abstract":["<h4>Introduction</h4>MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.<h4>Methods</h4>Fifteen SNPs were genotyped in the MASP1 gene in 350 blood donors. Corresponding plasma concentrations of MASP-1, MASP-3, and MAp44 were measured.<h4>Results</h4>A total of 10 different SNPs showed associations with the concentration of one or some of the three proteins (rs113938200, rs190590338, rs35089177, rs3774275, rs67143992, rs698090, rs72549154, rs72549254, rs75284004, rs7625133), and s"],"journal":["PloS one"],"pubmed_title":["Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44."],"pmcid":["PMC3759447"],"funding_grant_id":["RC2 HL102926","RC2 HL102925","UC2 HL102923","RC2 HL102924","RC2 HL102923","UC2 HL102924","UC2 HL102925","HL-103010","UC2 HL102926","RC2 HL103010","HL-102925","HL-102926","HL-102923","HL-102924","UC2 HL103010"],"pubmed_authors":["Ammitzboll CG","Thiel S","Stengaard-Pedersen K","Steffensen R","Jensenius JC","Jorgen Nielsen H","Bogsted M"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44.","description":"<h4>Introduction</h4>MASP-1 is the first protein in the activation of the lectin pathway and MASP-1 is, like its isoforms MASP-3 and MAp44, encoded by the MASP1 gene. Our aim was to explore associations between polymorphisms in MASP1 and corresponding concentrations of MASP-1, MASP-3, and MAp44 in plasma as well as the genetic contribution to the equilibrium between the three proteins.<h4>Methods</h4>Fifteen SNPs were genotyped in the MASP1 gene in 350 blood donors. Corresponding plasma concentrations of MASP-1, MASP-3, and MAp44 were measured.<h4>Results</h4>A total of 10 different SNPs showed associations with the concentration of one or some of the three proteins (rs113938200, rs190590338, rs35089177, rs3774275, rs67143992, rs698090, rs72549154, rs72549254, rs75284004, rs7625133), and s","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-02T12:20:21.033Z","creation":"2026-04-07T18:00:34.312Z"},"accession":"S-EPMC3759447","cross_references":{"pubmed":["24023860"],"doi":["10.1371/journal.pone.0073317"]}}