{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Armstrong DR"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["8820-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3761191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(32)"],"pubmed_abstract":["Studied extensively in solution and in the solid state, Li(TMP) (TMP=2,2,6,6-tetramethylpiperidide) is an important utility reagent popular as a strongly basic, weakly nucleophilic tool for C-H metallation. Recently, there has been a surge in interest in mixed metal derivatives containing the bulky TMP anion. Herein, we start to develop hetero (alkali metal) TMP chemistry by reporting the N,N,N',N'-tetramethylethylenediamine (TMEDA)-hemisolvated sodium-lithium cycloheterodimer [(tmeda)Na(μ-tmp)(2) Li], and its TMEDA-free variant [{Na(μ-tmp)Li(μ-tmp)}(∞)], which provides a rare example of a crystallographically authenticated polymeric alkali metal amide. Experimental observations suggest that the former is a kinetic intermediate en route to the latter thermodynamic product. Furthermore, a t"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Developing a hetero-alkali-metal chemistry of 2,2,6,6-tetramethylpiperidide (TMP): stoichiometric and structural diversity within a series of lithium/sodium, lithium/potassium and sodium/potassium TMP compounds."],"pmcid":["PMC3761191"],"funding_grant_id":["EP/F063733/1"],"pubmed_authors":["Armstrong DR","Robertson SD","Kennedy AR","Mulvey RE"],"additional_accession":[]},"is_claimable":false,"name":"Developing a hetero-alkali-metal chemistry of 2,2,6,6-tetramethylpiperidide (TMP): stoichiometric and structural diversity within a series of lithium/sodium, lithium/potassium and sodium/potassium TMP compounds.","description":"Studied extensively in solution and in the solid state, Li(TMP) (TMP=2,2,6,6-tetramethylpiperidide) is an important utility reagent popular as a strongly basic, weakly nucleophilic tool for C-H metallation. Recently, there has been a surge in interest in mixed metal derivatives containing the bulky TMP anion. Herein, we start to develop hetero (alkali metal) TMP chemistry by reporting the N,N,N',N'-tetramethylethylenediamine (TMEDA)-hemisolvated sodium-lithium cycloheterodimer [(tmeda)Na(μ-tmp)(2) Li], and its TMEDA-free variant [{Na(μ-tmp)Li(μ-tmp)}(∞)], which provides a rare example of a crystallographically authenticated polymeric alkali metal amide. Experimental observations suggest that the former is a kinetic intermediate en route to the latter thermodynamic product. Furthermore, a t","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2025-04-19T02:34:18.881Z","creation":"2019-03-27T01:15:27Z"},"accession":"S-EPMC3761191","cross_references":{"pubmed":["21766365"],"doi":["10.1002/chem.201101167"]}}