biostudies-literatureUnknown11(5)Panaccione I<h4>Objectives</h4>To review the role of Wnt pathways in the neurodevelopment of schizophrenia.<h4>Methods</h4>SYSTEMATIC PUBMED SEARCH, USING AS KEYWORDS ALL THE TERMS RELATED TO THE WNT PATHWAYS AND CROSSING THEM WITH EACH OF THE FOLLOWING AREAS: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.<h4>Results</h4>Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-caCurrent neuropharmacology535-58https://www.ebi.ac.uk/biostudies/studies/S-EPMC3763761biostudies-literatureNeurodevelopment in schizophrenia: the role of the wnt pathways.PMC3763761De Chiara LCaccia FManfredi GKotzalidis GDJaniri DPanaccione IForte AMDanese EGirardi PSimonetti AAmbrosi ESavoja VBrugnoli CNicoletti FRapinesi CNapoletano FMotolese MSani GDel Casale ASerata DCuomo IfalseNeurodevelopment in schizophrenia: the role of the wnt pathways.<h4>Objectives</h4>To review the role of Wnt pathways in the neurodevelopment of schizophrenia.<h4>Methods</h4>SYSTEMATIC PUBMED SEARCH, USING AS KEYWORDS ALL THE TERMS RELATED TO THE WNT PATHWAYS AND CROSSING THEM WITH EACH OF THE FOLLOWING AREAS: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.<h4>Results</h4>Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-ca2013-01-01T00:00:00Z2013 Sep2025-04-22T07:42:23.26Z2019-03-27T01:15:33ZS-EPMC37637612440387710.2174/1570159X113119990037