{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(3)"],"submitter":["Miyamoto T"],"pubmed_abstract":["Macrophages play a pivotal role in host defense against multiple foreign materials such as bacteria, parasites and artificial devices. Some macrophage lineage cells, namely osteoclasts and foreign body giant cells (FBGCs), form multi-nuclear giant cells by the cell-cell fusion of mono-nuclear cells. Osteoclasts are bone-resorbing cells, and are formed in the presence of RANKL on the surface of bones, while FBGCs are formed in the presence of IL-4 or IL-13 on foreign materials such as artificial joints, catheters and parasites. Recently, fusiogenic mechanisms and the molecules required for the cell-cell fusion of these macrophage lineage cells were, at least in part, clarified. Dendritic cell specific transmembrane protein (DC-STAMP) and osteoclast stimulatory transmembrane protein (OC-STAM"],"journal":["JAK-STAT"],"pagination":["e24777"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3772113"],"repository":["biostudies-literature"],"pubmed_title":["STATs and macrophage fusion."],"pmcid":["PMC3772113"],"pubmed_authors":["Miyamoto T"],"additional_accession":[]},"is_claimable":false,"name":"STATs and macrophage fusion.","description":"Macrophages play a pivotal role in host defense against multiple foreign materials such as bacteria, parasites and artificial devices. Some macrophage lineage cells, namely osteoclasts and foreign body giant cells (FBGCs), form multi-nuclear giant cells by the cell-cell fusion of mono-nuclear cells. Osteoclasts are bone-resorbing cells, and are formed in the presence of RANKL on the surface of bones, while FBGCs are formed in the presence of IL-4 or IL-13 on foreign materials such as artificial joints, catheters and parasites. Recently, fusiogenic mechanisms and the molecules required for the cell-cell fusion of these macrophage lineage cells were, at least in part, clarified. Dendritic cell specific transmembrane protein (DC-STAMP) and osteoclast stimulatory transmembrane protein (OC-STAM","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jul","modification":"2025-05-29T21:30:06.348Z","creation":"2025-05-29T21:30:06.348Z"},"accession":"S-EPMC3772113","cross_references":{"pubmed":["24069561"],"doi":["10.4161/jkst.24777"]}}