{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(9)"],"submitter":["Ito S"],"pubmed_abstract":["Vasohibin-1 (VASH1) is isolated as an endogenous angiogenesis inhibitor produced by the vascular endothelium. We previously reported that tumor growth and tumor angiogenesis were augmented in VASH1 (-/-) mice. Here we examined whether VASH1 plays any role in cancer metastasis. When Lewis lung carcinoma (LLC) cells were inoculated in the footpad to observe spontaneous metastasis, a significant increase in lung metastasis together with inguinal lymph node metastasis was evident in the VASH1 (-/-) mice. Histological analyses revealed that vessels of the footpad tumor in VASH1 (-/-) mice were more immature, having fewer mural cells. However, when LLC cells were injected into a tail vein, the extent of lung metastasis was unchanged between wild-type mice and VASH1 (-/-) mice. When VASH1 in endo"],"journal":["PloS one"],"pagination":["e73931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3774736"],"repository":["biostudies-literature"],"pubmed_title":["Enhanced cancer metastasis in mice deficient in vasohibin-1 gene."],"pmcid":["PMC3774736"],"pubmed_authors":["Miyashita H","Satomi S","Suzuki Y","Ito S","Kobayashi M","Sato Y"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced cancer metastasis in mice deficient in vasohibin-1 gene.","description":"Vasohibin-1 (VASH1) is isolated as an endogenous angiogenesis inhibitor produced by the vascular endothelium. We previously reported that tumor growth and tumor angiogenesis were augmented in VASH1 (-/-) mice. Here we examined whether VASH1 plays any role in cancer metastasis. When Lewis lung carcinoma (LLC) cells were inoculated in the footpad to observe spontaneous metastasis, a significant increase in lung metastasis together with inguinal lymph node metastasis was evident in the VASH1 (-/-) mice. Histological analyses revealed that vessels of the footpad tumor in VASH1 (-/-) mice were more immature, having fewer mural cells. However, when LLC cells were injected into a tail vein, the extent of lung metastasis was unchanged between wild-type mice and VASH1 (-/-) mice. When VASH1 in endo","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-26T13:53:47.145Z","creation":"2019-03-26T23:21:08Z"},"accession":"S-EPMC3774736","cross_references":{"pubmed":["24066086"],"doi":["10.1371/journal.pone.0073931"]}}