biostudies-literatureChen HNCRR NIH HHSNHLBI NIH HHSNCI NIH HHSNIGMS NIH HHS650-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3776216biostudies-literatureUnknown3(9)We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 °C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo- and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica matrix as was believed previously. The calcination does not impact the particles' abilities to load drugs and conjugate to biomolecules. In a proof-of-concept study, we demonstrated that doxorubicin (Dox) can be efficiently encapsulated into these fluorescent mesoporous silica nanoparticles. After coupled to c(RGDyK), the nanoconjugates can efficiently home to tumors through interactions with integrin αvβ3 overexpressed on the tumor vasculature. This calcination-induced luminescence is expected to find wide applications in silica-based drug delivery, nanoparticle coating, and immunofluorescence imaging.TheranosticsLabel-free luminescent mesoporous silica nanoparticles for imaging and drug delivery.PMC3776216R00 CA153772RR005351/GM103390P41 RR005351R01 HL0933395R00CA153772P41 GM103390Pan ZXie JChuang YJChen HZhen ZTang WTodd TWang LfalseLabel-free luminescent mesoporous silica nanoparticles for imaging and drug delivery.We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 °C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo- and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica matrix as was believed previously. The calcination does not impact the particles' abilities to load drugs and conjugate to biomolecules. In a proof-of-concept study, we demonstrated that doxorubicin (Dox) can be efficiently encapsulated into these fluorescent mesoporous silica nanoparticles. After coupled to c(RGDyK), the nanoconjugates can efficiently home to tumors through interactions with integrin αvβ3 overexpressed on the tumor vasculature. This calcination-induced luminescence is expected to find wide applications in silica-based drug delivery, nanoparticle coating, and immunofluorescence imaging.2013-01-01T00:00:00Z20132025-04-04T19:30:19.479Z2019-03-27T01:16:10ZS-EPMC37762162405280510.7150/thno.6668