{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(9)"],"submitter":["Kim MK"],"pubmed_abstract":["Background
Agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucokinase activators (GKA) act as antidiabetic agents by their ability protect beta cells, and stimulate insulin secretion. Oxidative and endoplasmic reticulum (ER) stresses aggravate type 2 diabetes by causing beta cell loss. It was shown that GLP-1R agonists protect beta cells from oxidative and ER stresses. On the other hand, little is known regarding how GKAs protect beta cells. We hypothesized that GKAs protect beta cells by mechanisms distinct from those underlying GLP-1R agonist and tested our hypothesis by comparing the molecular effects of exenatide, a GLP-1R agonist, and piragliatin, a GKA, on INS-1 cells under oxidative and ER-induced stresses.Methods
BETA CELLS WERE TREATED WITH STREPTOZOTOCI"],"journal":["PloS one"],"pagination":["e73340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3777936"],"repository":["biostudies-literature"],"pubmed_title":["Differential protective effects of exenatide, an agonist of GLP-1 receptor and Piragliatin, a glucokinase activator in beta cell response to streptozotocin-induced and endoplasmic reticulum stresses."],"pmcid":["PMC3777936"],"pubmed_authors":["Cho JH","Cheong YH","Lee JJ","Son MH","Kim MK","Lee KJ"],"additional_accession":[]},"is_claimable":false,"name":"Differential protective effects of exenatide, an agonist of GLP-1 receptor and Piragliatin, a glucokinase activator in beta cell response to streptozotocin-induced and endoplasmic reticulum stresses.","description":"Background
Agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucokinase activators (GKA) act as antidiabetic agents by their ability protect beta cells, and stimulate insulin secretion. Oxidative and endoplasmic reticulum (ER) stresses aggravate type 2 diabetes by causing beta cell loss. It was shown that GLP-1R agonists protect beta cells from oxidative and ER stresses. On the other hand, little is known regarding how GKAs protect beta cells. We hypothesized that GKAs protect beta cells by mechanisms distinct from those underlying GLP-1R agonist and tested our hypothesis by comparing the molecular effects of exenatide, a GLP-1R agonist, and piragliatin, a GKA, on INS-1 cells under oxidative and ER-induced stresses.Methods
BETA CELLS WERE TREATED WITH STREPTOZOTOCI","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-25T23:00:29.998Z","creation":"2019-03-26T23:21:11Z"},"accession":"S-EPMC3777936","cross_references":{"pubmed":["24069189"],"doi":["10.1371/journal.pone.0073340"]}}