biostudies-literature00450Sam BNIGMS NIH HHS3790-3https://www.ebi.ac.uk/biostudies/studies/S-EPMC3779475biostudies-literatureUnknown15(14)Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.Organic lettersRuthenium catalyzed reductive coupling of paraformaldehyde to trifluoromethyl allenes: CF3-bearing all-carbon quaternary centers.PMC3779475R01 GM069445Krische MJMontgomery TPSam B45falseRuthenium catalyzed reductive coupling of paraformaldehyde to trifluoromethyl allenes: CF3-bearing all-carbon quaternary centers.Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.2013-01-01T00:00:00Z2013 Jul2020-10-29T11:45:51Z2019-03-27T01:16:23ZS-EPMC37794752384167810.1021/ol401771a