{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim SH"],"funding":["BLRD VA","NIEHS NIH HHS"],"pagination":["70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3782349"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1"],"pubmed_abstract":["<h4>Background</h4>Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer's disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive. At present, recognized acquired risks for AD include traumatic brain injury, hypercholesterolemia, obesity, hypertension, and type 2 diabetes.<h4>Methods</h4>Based on reports associating various inhalants with AD pathology, we investigated the possibility that air pollution might contribute to AD risk by exposing wild-type mice to a standard air pollution modeling system employing nickel nanoparticle-enriched atmosphere for 3 hr.<h4>Results</h4>Mice exposed to air pollution showed 72-129% increases in brain levels of both amyloid-β peptides Aβ40 and Aβ42, as well as Aβ42/"],"journal":["F1000Research"],"pubmed_title":["Rapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution."],"pmcid":["PMC3782349"],"funding_grant_id":["I01 BX000348","P30 ES000260","U01 ES020126"],"pubmed_authors":["Gandy S","Chen LC","Kim SH","Knight EM","Cuevas AK","Saunders EL","Popovech M"],"additional_accession":[]},"is_claimable":false,"name":"Rapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution.","description":"<h4>Background</h4>Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer's disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive. At present, recognized acquired risks for AD include traumatic brain injury, hypercholesterolemia, obesity, hypertension, and type 2 diabetes.<h4>Methods</h4>Based on reports associating various inhalants with AD pathology, we investigated the possibility that air pollution might contribute to AD risk by exposing wild-type mice to a standard air pollution modeling system employing nickel nanoparticle-enriched atmosphere for 3 hr.<h4>Results</h4>Mice exposed to air pollution showed 72-129% increases in brain levels of both amyloid-β peptides Aβ40 and Aβ42, as well as Aβ42/","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-20T03:22:20.886Z","creation":"2019-03-27T01:16:29Z"},"accession":"S-EPMC3782349","cross_references":{"pubmed":["24358824"],"doi":["10.12688/f1000research.1-70.v1"]}}