biostudies-literatureKim SHBLRD VANIEHS NIH HHS70https://www.ebi.ac.uk/biostudies/studies/S-EPMC3782349biostudies-literatureUnknown1<h4>Background</h4>Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer's disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive. At present, recognized acquired risks for AD include traumatic brain injury, hypercholesterolemia, obesity, hypertension, and type 2 diabetes.<h4>Methods</h4>Based on reports associating various inhalants with AD pathology, we investigated the possibility that air pollution might contribute to AD risk by exposing wild-type mice to a standard air pollution modeling system employing nickel nanoparticle-enriched atmosphere for 3 hr.<h4>Results</h4>Mice exposed to air pollution showed 72-129% increases in brain levels of both amyloid-β peptides Aβ40 and Aβ42, as well as Aβ42/F1000ResearchRapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution.PMC3782349I01 BX000348P30 ES000260U01 ES020126Gandy SChen LCKim SHKnight EMCuevas AKSaunders ELPopovech MfalseRapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution.<h4>Background</h4>Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer's disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive. At present, recognized acquired risks for AD include traumatic brain injury, hypercholesterolemia, obesity, hypertension, and type 2 diabetes.<h4>Methods</h4>Based on reports associating various inhalants with AD pathology, we investigated the possibility that air pollution might contribute to AD risk by exposing wild-type mice to a standard air pollution modeling system employing nickel nanoparticle-enriched atmosphere for 3 hr.<h4>Results</h4>Mice exposed to air pollution showed 72-129% increases in brain levels of both amyloid-β peptides Aβ40 and Aβ42, as well as Aβ42/2012-01-01T00:00:00Z20122025-04-20T03:22:20.886Z2019-03-27T01:16:29ZS-EPMC37823492435882410.12688/f1000research.1-70.v1