{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Voikar V"],"funding":["NIA NIH HHS","NINDS NIH HHS"],"pagination":["69-78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3784023"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["238"],"pubmed_abstract":["The LRRTM family proteins have been shown to act as synaptogenic cell adhesion molecules via interaction with presynaptic neurexins and are associated with neuropsychiatric disorders. LRRTM1-knockout mice have subtle morphological deficits in excitatory hippocampal synapses and were suggested to have impaired cognitive function. Here we report that LRRTM1-knockout mice exhibit an extraordinary phenotype of avoiding small enclosures. In the light-dark box, the knockout mice escape to dark through a standard opening as quickly as wild-type littermates but avoid escaping through a small doorway. While all wild-type mice spontaneously enter a small tube, most knockout mice do not. This apparent aversion to enter narrow space may explain other abnormalities such as increased time in open arms i"],"journal":["Behavioural brain research"],"pubmed_title":["LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour."],"pmcid":["PMC3784023"],"funding_grant_id":["R01 AG034924","R37 NS033020","R01 NS074319"],"pubmed_authors":["Voikar V","Lauren J","Kulesskaya N","Laakso T","Airaksinen MS","Strittmatter SM"],"additional_accession":[]},"is_claimable":false,"name":"LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour.","description":"The LRRTM family proteins have been shown to act as synaptogenic cell adhesion molecules via interaction with presynaptic neurexins and are associated with neuropsychiatric disorders. LRRTM1-knockout mice have subtle morphological deficits in excitatory hippocampal synapses and were suggested to have impaired cognitive function. Here we report that LRRTM1-knockout mice exhibit an extraordinary phenotype of avoiding small enclosures. In the light-dark box, the knockout mice escape to dark through a standard opening as quickly as wild-type littermates but avoid escaping through a small doorway. While all wild-type mice spontaneously enter a small tube, most knockout mice do not. This apparent aversion to enter narrow space may explain other abnormalities such as increased time in open arms i","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2025-04-19T14:44:39.654Z","creation":"2019-03-27T01:16:32Z"},"accession":"S-EPMC3784023","cross_references":{"pubmed":["23089646"],"doi":["10.1016/j.bbr.2012.10.013"]}}